🏈StatLine
Week 4Final
WinnerJAX

Jacksonville Jaguars

(11-4)26
–
SF

San Francisco 49ers

(11-4)21
Sunday, September 28, 2025
8:05 PM UTC
Levi's Stadium · Santa Clara, CA

Head-to-Head History

Jacksonville Jaguars vs San Francisco 49ers(2021-2025)

Series is tied

JAX (1)2 games(1) SF
50%50%

Avg Points/Game

JAX

18.0

vs

SF

25.5

Highest Score

JAX

26

vs

SF

30

Lowest Score

JAX

10

vs

SF

21

Current Streak

JAX

1W

JAX Home/Away

Home

0-1

Away

1-0

Biggest Win

SF

+20

2021 Week 11

Game History(2 games)
SeasonWeekDateJAXScoreSF
2025Wk 4Sep 28, 2025A26-21H
2021Wk 11Nov 21, 2021H10-30A

Team Rosters

Jacksonville JaguarsAway
1QB
Trevor Lawrence3,489 pass yds, 26 TD
2RB
Travis Etienne Jr.999 rush yds, 7 TD
3WR
Parker Washington645 rec yds, 4 TD
4WR
Brian Thomas Jr.619 rec yds, 2 TD
5TE
Brenton Strange434 rec yds, 2 TD
San Francisco 49ersHome
1RB
Christian McCaffrey1,039 rush yds, 9 TD
2TE
George Kittle599 rec yds, 7 TD
3WR
Jauan Jennings566 rec yds, 8 TD
4QB
Brock Purdy1,737 pass yds, 17 TD
5QB
Mac Jones2,151 pass yds, 13 TD