🏈StatLine
Week 16Final
WinnerSF

San Francisco 49ers

(11-4)48
–
IND

Indianapolis Colts

(8-7)27
Tuesday, December 23, 2025
1:15 AM UTC
Lucas Oil Stadium · Indianapolis, IN

Head-to-Head History

San Francisco 49ers vs Indianapolis Colts(2021-2025)

Series is tied

SF (1)2 games(1) IND
50%50%

Avg Points/Game

SF

33.0

vs

IND

28.5

Highest Score

SF

48

vs

IND

30

Lowest Score

SF

18

vs

IND

27

Current Streak

SF

1W

SF Home/Away

Home

0-1

Away

1-0

Biggest Win

SF

+21

2025 Week 16

Game History(2 games)
SeasonWeekDateSFScoreIND
2025Wk 16Dec 23, 2025A48-27H
2021Wk 7Oct 25, 2021H18-30A

Team Rosters

San Francisco 49ersAway
1RB
Christian McCaffrey1,039 rush yds, 9 TD
2TE
George Kittle599 rec yds, 7 TD
3WR
Jauan Jennings566 rec yds, 8 TD
4QB
Brock Purdy1,737 pass yds, 17 TD
5QB
Mac Jones2,151 pass yds, 13 TD
Indianapolis ColtsHome
1RB
Jonathan Taylor1,489 rush yds, 17 TD
2QB
Daniel Jones3,101 pass yds, 19 TD
3WR
Michael Pittman Jr.757 rec yds, 7 TD
4TE
Tyler Warren748 rec yds, 4 TD
5WR
Alec Pierce871 rec yds, 4 TD