🏈StatLine
Week 3Final
ARI

Arizona Cardinals

(3-12)15
–
WinnerSF

San Francisco 49ers

(11-4)16
Sunday, September 21, 2025
8:25 PM UTC
Levi's Stadium · Santa Clara, CA

Head-to-Head History

Arizona Cardinals vs San Francisco 49ers(2020-2025)

Arizona Cardinals leads the all-time series

ARI (5)8 games(3) SF
63%38%

Avg Points/Game

ARI

24.0

vs

SF

21.4

Highest Score

ARI

47

vs

SF

41

Lowest Score

ARI

12

vs

SF

10

Current Streak

SF

2W

ARI Home/Away

Home

2-2

Away

3-1

Biggest Win

ARI

+23

2024 Week 18

Game History(8 games)
SeasonWeekDateARIScoreSF
2025Wk 11Nov 16, 2025H22-41A
2025Wk 3Sep 21, 2025A15-16H
2024Wk 18Jan 5, 2025H47-24A
2024Wk 5Oct 6, 2024A24-23H
2021Wk 9Nov 7, 2021A31-17H
2021Wk 5Oct 10, 2021H17-10A
2020Wk 16Dec 26, 2020H12-20A
2020Wk 1Sep 13, 2020A24-20H

Team Rosters

Arizona CardinalsAway
1TE
Trey McBride1,098 rec yds, 10 TD
2QB
Jacoby Brissett2,911 pass yds, 19 TD
3WR
Michael Wilson818 rec yds, 5 TD
4WR
Marvin Harrison Jr.608 rec yds, 4 TD
5QB
Kyler Murray962 pass yds, 6 TD
San Francisco 49ersHome
1RB
Christian McCaffrey1,039 rush yds, 9 TD
2TE
George Kittle599 rec yds, 7 TD
3WR
Jauan Jennings566 rec yds, 8 TD
4QB
Brock Purdy1,737 pass yds, 17 TD
5QB
Mac Jones2,151 pass yds, 13 TD