🏈StatLine
Week 3Final
ARI

Arizona Cardinals

(3-13)15
–
WinnerSF

San Francisco 49ers

(12-5)16
Sunday, September 21, 2025
8:25 PM UTC
Levi's Stadium · Santa Clara, CA

Head-to-Head History

Arizona Cardinals vs San Francisco 49ers(2021-2025)

Arizona Cardinals leads the all-time series

ARI (4)6 games(2) SF
67%33%

Avg Points/Game

ARI

26.0

vs

SF

21.8

Highest Score

ARI

47

vs

SF

41

Lowest Score

ARI

15

vs

SF

10

Current Streak

SF

2W

ARI Home/Away

Home

2-1

Away

2-1

Biggest Win

ARI

+23

2024 Week 18

Game History(6 games)
SeasonWeekDateARIScoreSF
2025Wk 11Nov 16, 2025H22-41A
2025Wk 3Sep 21, 2025A15-16H
2024Wk 18Jan 5, 2025H47-24A
2024Wk 5Oct 6, 2024A24-23H
2021Wk 9Nov 7, 2021A31-17H
2021Wk 5Oct 10, 2021H17-10A

Team Rosters

Arizona CardinalsAway
1TE
Trey McBride1,174 rec yds, 11 TD
2QB
Jacoby Brissett3,123 pass yds, 21 TD
3WR
Michael Wilson907 rec yds, 6 TD
4WR
Marvin Harrison Jr.608 rec yds, 4 TD
5QB
Kyler Murray962 pass yds, 6 TD
San Francisco 49ersHome
1RB
Christian McCaffrey1,202 rush yds, 10 TD
2QB
Brock Purdy2,167 pass yds, 20 TD
3WR
Jauan Jennings643 rec yds, 9 TD
4TE
George Kittle628 rec yds, 7 TD
5QB
Mac Jones2,151 pass yds, 13 TD